Dihydrotestosterone (DHT) is a potent and highly energetic androgen implicated for man pattern hair loss. Dihydrotestosterone is produced mainly in the prostate gland, souffrance, adrenal glands and hair follicles. The formation of dihydrotestosterone involved testosterone as a prohormone. Testosterone is digested by either of the two types of isoenzymes: 5-alpha reductase type I and 5-alpha reductase type II changing it to a more active dihydro- form.
Androgen target cells are the sites of dihydrotestosterone formation which include the androgen dependent and androgen sensitive regions in the body. In the androgen sensitive region, the nuclear membrane and microsomes take part in the conversion process. Although, testosterone is produced mainly in the testes, production of dihydrotestosterone occurs any place in the body where testosterone has entered the cells of the androgen dependent tissue. Within the remaining hair, the androgen dependent locations include the frontotemporal region, the crown and the vertex. Essentially, these are the websites where hair tumble occurs at the onset of male pattern tresses loss.
In the androgen dependent regions on the scalp, testosterone is changed to dihydrotestosterone. Dihydrotestosterone then binds to the vom männlichen geschlechtshormon receptors in the hair follicles. The androgen receptors actually bind both testosterone and dihydrotestosterone. However , the dihydro- form has higher affinity to and dissociates more slowly from the receptors. Thus, higher levels of the hormone are retained in the receptors. The occurrence of the androgens in the masteron hair follicles actually facilitates hair growth. On the other hand, in genetically predisposed individuals, high degrees of DHT can prevent hair growth, even completely stopping it. As a result, the influenced area on the scalp steadily thins and may change completely bald. Even if baldness have not yet took place, the damaged may still look bald because of progressive miniaturization of hair. Normally, this sort of tresses loss starts during puberty where the body produces high levels of androgenic hormone or testosterone.
Dihydrotestosterone can only put in its unwanted effects on susceptible individuals. Male pattern hair loss is heritable. Folks who inherit the gene that predisposes the condition become susceptible to the action of DHT. They will are likely to experience hair shedding during growing up nonetheless they may well not really notice it until after 30 where significant amount of hair was lost. Typically the condition impacts more than 50 percent of men, but the same condition is also recognized in women.
At present, the male pattern hair loss has no cure. People, however, can find treatments that can stop tresses loss effectively. Because the role of DHT has already been recognized and widely accepted, the suggested treatment for the condition is one which addresses the situation with DHT. The DHT levels on the scalp should be maintained at levels where it cannot cause harm to the head of hair follicles. This can be done by instituting treatments that prevent the production of the hormone such as treatments that inhibit the enzyme that catalyzes the conversion process. The drugs minoxidil and finasteride are known as DHT blockers because they work mainly by blocking the conversion process. Both drugs are proven effective in stopping male pattern tresses loss. They can also opt for natural treatments that blocks DHT and promotes hair regrowth.