Dihydrotestosterone (DHT) is a potent and highly lively androgen implicated for male pattern hair loss. Dihydrotestosterone is produced mostly in the prostate gland, souffrance, adrenal glands and curly hair follicles. The organization of dihydrotestosterone involved testosterone as a prohormone. Testosterone is digested by either of the two types of isoenzymes: 5-alpha reductase type We and 5-alpha reductase type II changing it to a more active dihydro- form.
Androgen target tissues are the sites of dihydrotestosterone formation which include the androgen dependent and androgen sensitive regions in the body. In the androgen sensitive region, the nuclear membrane and microsomes are involved in the conversion process. Although, testosterone is produced mainly in the examen, production of dihydrotestosterone occurs anywhere in the body where testosterone has entered the cells of the androgen dependent tissue. In the remaining hair, the androgen dependent areas include the frontotemporal region, the crown and the vertex. Essentially, these are web sites where hair drop occurs at the starting point of male pattern hair loss.
Dihydrotestosterone and Man Pattern Hair Loss
Within the androgen dependent regions on masteron the scalp, testo-sterone is converted to dihydrotestosterone. Dihydrotestosterone then binds to the androgen receptors in the hair follicles. The androgen receptors actually bind both testosterone and dihydrotestosterone. On the other hand, the dihydro- form has higher affinity to and dissociates more slowly from the receptors. Thus, higher levels of the body hormone are retained in the receptors. The existence of the androgens in the hair follicles actually facilitates hair growth. However, in genetically predisposed individuals, high levels of DHT can prevent hair growth, even completely stopping it. Because a result, the influenced area on the remaining hair steadily thins and may turn completely bald. Actually if baldness has not yet occurred, the damaged may still look balding because of progressive miniaturization of hair. Normally, this type of hair reduction starts during puberty where the body produces high levels of testosterone.
Dihydrotestosterone can only exert their negative effects on susceptible individuals. Male pattern tresses loss is heritable. Folks who inherit the gene that predisposes the situation become susceptible to the action of DHT. They are likely to experience hair dropping during puberty nonetheless they might not exactly really notice it until after thirty where significant level of hair was lost. The situation influences more than fifty percent of men, but the same condition is also discovered in women.
At present, you design hair loss has no cure. Affected individuals, however, can find treatments that can stop hair damage effectively. Since the role of DHT has been recognized and widely accepted, the suggested treatment for the condition is the one that addresses the challenge with DHT. The DHT levels on the scalp should be maintained at levels where it cannot harm the hair follicles. This can be done by instituting treatments that block the creation of the hormone such as treatments that lessen the enzyme that catalyzes the conversion process. Typically the drugs minoxidil and finasteride are known as DHT blockers because they work mainly by blocking the conversion process. Both drugs are proven effective in stopping male pattern curly hair loss. They can also choose for natural treatments that blocks DHT and stimulates hair regrowth.