In Japan, Kobayashi Pharmaceutical's "Meiwanmo" (840 tablets, a 70-day supply/420 tablets, a 35-day supply) is hormone-free. It helps alleviate the effects of aging, such as insomnia, irritability, physiological abnormalities, menstrual pain, pain in the lower back and abdomen, sensitivity to cold, ringing in the ears, palpitations, anemia, acne, constipation, abnormal blood pressure, headaches, and more. It can also be used by younger women to regulate hormones and address menstrual irregularities.