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The incidence of male infertility is increasing worldwide, and has become an important problem that plagues many married couples. Half of the infertility cases have induced by male infertility. Wuzi Yanzong Pill is a traditional Chinese herbal formula used for spermatorrhea, premature ejaculation, erectile dysfunction, lumbago and male sterility widely. Therefore, in this systematic review, we design to evaluate the effectiveness and safety of Wuzi-Yanzong Pill for the forment of male infertility. 同仁堂五子丸衍宗丸阳痿早泄治疗男用中药\n\n60g / Pack,\n\ntake 60 pills(6g) each time, 2 times per day\n\nTonifies the Kidneys, Nourishes Jing-essence, Benefits the Eyes Ingredients: Five Ancestors Teapills - Wu Zi Yan Zong Wan contains Lycium chinense fruit, Cuscuta chinensis seed, Rubus chingii fruit, Plantago asiatica seed, Schisandra chinensis fruit. -Gou qi zi, Tu si zi, Fu pen zi, Che qian zi, Wu wei zi.