Made in Japan, Rot 40A Cooling Eye Drops contain four vitamins and amino acids to revitalize your eyes. Soothing and instantly cooling, they increase blood flow to the eyes and alleviate blurred vision, itchy, allergic, red, and tired eyes. The vitamins contained in the eye drops replenish tear production. These all-purpose, fast acting eye drops soothe for up to 8 hours. They come in a 12ml bottle with a twist-off cap. It's important to store the drops in conditions below 77 degrees Fahrenheit.